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基础医学系

履历

    2015- 至今 清华大学 教授
    2009-2015 清华大学 副教授
    2003-2009 美国国立卫生研究院传染病与变态反应病研究所免疫实验室 博士后
    1997-2003 美国得克萨斯州加尔韦斯顿医学院 研究助理
                      美国得克萨斯州加尔韦斯顿医学院实验病理学  博士
    1991-1996 北京医科大学临床医学 学士

研究领域与方向

研究围绕体液免疫应答调节机制,关注免疫细胞迁徙、动态互作、及组织微环境对其功能发育的影 响。通过经典遗传、生化、细胞免疫学手段,及双光子显微镜活细胞、活组织动态成像方法
1. 生发中心反应关键性细胞互作的分子机理;
2. 细胞互作的定性及定量特点如何参与细胞命运选择;
3. 生发中心及滤泡组织结构的时空动态演化特点及分子调控机制;
4. 以上3个层次的组织与调节机制如何保持免疫系统在产生有效应答的同时避免自身反应。

学术荣誉与奖励

    2018    第四届树兰医学青年奖

    2018    美国免疫学家协会研究者奖(AAI-BD Biosciences Investigator Award

    2017    药明康德生命化学研究奖

    2017    霍华德休斯医学研究所国际学者(HHMI International Research Scholar

    2016    吴阶平-保罗杨森医学药学奖

    2016    第十一届华人生物学家协会青年奖

    2015    谈家桢生命科学创新奖

    2014    科技部中青年科技创新领军人才

    2014    国家杰出青年基金获得者

    2013    科技部“973”计划首席科学家

    2013    清华大学先进工作者

    2013     “科学研究优秀人才,《中国细胞生物学学报》

    2013    清华大学学术新人奖

    2010    教育部2009年度新世纪优秀人才

    2009    “Scopus未来科学之星金奖,《科学新闻》与 Elsevier


关键词

2-photon microscopy, antibody, cell migration, follicular t-helper cells, germinal centers, tissue patterning

代表性论文

1.Yifeng Wang*, Jingwen Shi*, Jiacong Yan*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi#. Germinal center development of memory B cells driven by Interleukin-9-producing follicular T-helper cells. Nature Immunology, 18:921-930, 2017.

2.Peiwen Lu*, Changming Shih*, and Hai Qi#. Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264, 2017.

3.Hu Yan*, Longyan Wu*, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, and Hai Qi#. Plexin B2 and Semaphorin 4C guide T-cell recruitment and function in the germinal center. Cell Reports, 19:995-1007, 2017.

4.Jiacong Yan, Bo Liu, Yan Shi, Hai Qi#. Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo. Journal of Experimental Medicine, 214:319, 2017.

5.Hai Qi#. T follicular helper cells in space-time. Nature Reviews Immunology, 16:612-625, 2016.

6.Xin Chen*, Shan Tang*, Ji-Shen Zheng*, Ruozhu Zhao, Zhi-Peng Wang, Wen Shao, Hao-Nan Chang, Jing-Yuan Cheng, Hui Zhao, Lei Liu#, and Hai Qi#. Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo. Nature Communications 6:7220, 2015.

7.Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015.

8.Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi#. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3? interactions. Journal of Immunology, 193:3860-3871, 2014.

9.Hai Qi#, Wolfgang Kastenmuller# and Ronald N Germain#. Spatio-temporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 30:141-167, 2014

10.Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#.Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.

11.Hai Qi*, Jennifer L. Cannons*, Frederick Klauschen, Pamela L. Schwartzberg, and Ronald N. Germain. SAP-controlled T-B cell interactions underlie germinal centre formation.Nature 455:764-769, 2008. (* co-first authors)

12.Hai Qi, Jackson G. Egen, Alex Y. C. Huang, and Ronald N. Germain. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006.


联系方式

Email: qihai at biowww.sfrecs.com

Phone: +86-10-62796757

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