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基础医学系

履历

    2000-2003      山东医学科学院 医学免疫学硕士

    2003-2006      中国科学技术大学 细胞生物学博士 

    2006-2011      加拿大蒙特利尔临床研究所 分子肿瘤学博士后

    2011-2017      清华大学免疫学研究所/医学院 研究员/Tenure-track Assistant Professor 

    2017/07-至今  清华大学免疫学研究所/医学院 研究员/Tenured Associate Professor 





研究领域与方向

NK 细胞活化受到其表面活化型和抑制性受体的精细调节。在正常情况下,主导抑制作用的小鼠Ly49家族和人KIR家族分子通过识别MHC-I类分子,使NK细胞保持耐受状态。然而,当病毒感染或应激状态下,细胞表面的MHC-I分子丢失或者针对NK细胞活化型受体的配体上调,NK细胞耐受状态将被破坏。因此,更好地在时间和空间水平了解NK细胞活化和功能获得机制,特别是NK细胞参与的细胞毒活性,将有助于设计基于NK细胞的生物治疗策略。我们特别对以下科学问题感兴趣:NK细胞发育过程相关的信号途径;NK细胞是如何在分子和细胞水平功能获得成熟;驱动NK细胞分化和活化的分子基础。

1. 肿瘤免疫微环境

2. NK细胞发育和功能获得机制 

3. NK细胞生物治疗策略研究



学术荣誉与奖励

    2017             国家基金委杰出青年基金

    2013             国家基金委优秀青年基金

    2012-2016    杨森-清华大学感染中心研究员奖  

    2008-2011    加拿大健康研究院CIHR博士后Fellowship

    2007             Angelo Pizzagalli 博士后Fellowship

    2006             中华医学科技奖一等奖(主要参与)

    2005             中科院院长奖(优秀奖)


关键词

肿瘤免疫学、NK细胞、SLAM家族受体

代表性论文

1.       Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec 19;47(6):1100-1113.

2.       Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M,Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong ZJ, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. Cell Res. 2017 Aug;27(8):1034-1045.

3.       Chen S#, Cai C#, Li Z#, Liu GW, Wang Y, Blonska M, Dan Li D, Du J, Lin X, Yang M, and Dong Z*. Genetic Dissection of SAP-dependent and SAP-independent SLAM Family Signaling in NKT Cell Development and Humoral Immunity, Journal Experimental Medicine. 2017 Jan 3. doi: 10.1084/jem.20161312. 

4.       Huang J, Yuan Q, Zhu H, Yin L, Hong S, Dong Z, Jin W, Dong C*. Interleukin-17C/IL-17RE amplifies T cell function in autoimmune hepatitis. J Immunol. 2016 Dec 12. pii: 1600977. 

5.       Chen S#, Yang M#, Du J, Li D, Li ZH, Cai C, Ma Y, Zhang Y, Tian Z*, and Dong Z*. The self-specific activation receptor SLAM family is critical to NK cell education. Immunity. 2016 Aug 16;45(2):292-304. 

6.       Yang M#, Chen S#, Du J, He J, Wang Y, Zehua, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z and Dong Z*. NK cell development requires Tsc1-dependent negative regulation of IL-15-trgiggered mTORC1 activation. Nature Communications. 2016 Sep 7;7:12730. doi: 10.1038/ncomms12730

7.       Wu N, Zhong MC, Roncagalli R, Pérez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A. A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nature Immunology. 2016 Apr;17(4):387-96.

8.       Du J, Yang MX, Chen SS, Li D, Chang Z, and Dong Z* PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene, 2016;35(25):3314-23.

9.       Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. Journal Experimental Medicine. 2015 212(2):253-65.

10.     Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W, Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. SAP-regulated T Cell-APC adhesion and ligation-dependent and-independent Ly108-CD3ζ interactions. J Immunol. 2014 Oct 15;193(8):3860-71. 

11.     Dong Z*, Dong C. Cancer-associated inflammation and tumor microenvironment. Cancer J. 2013 Nov-Dec;19(6):459-60. 

12.     Dong Z*, Davidson D, Pérez-Quintero L.A, Kurosaki T, Swat W, and Veillette A. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. Immunity, 2012; 36(6):974-85. 

13.     Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation. Blood;119(19):4349-57.

14.     Dong Z, Veillette A. How do SAP family deficiencies compromise immunity? Trends in Immunology; 2010 Aug;31(8):295-302

15.     Veillette A, Dong Z, Zhong M, Cruz-Munoz ME. Importance and mechanism of “switch” function of SAP family adaptors. Immunological Reviews. 2009,232(1); 2009:229-39.

16.     Dong Z, Cruz-Munoz ME, Zhong M, Chen R, Latour S and Veillette A. Essential role of SAP family adaptors in natural killer cell surveillance of hematopoietic cells. Nature Immunology; 10(9); (2009):973-80.

17.     Cruz-Munoz ME, Dong Z, Shi X, Zhang S, Veillette A. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nature Immunology; 10(3); (2009):297-305.

18.     Veillette A, Zhang S, Shi X, Dong Z, Davidson D and Zhong M. SAP expression in T cells, not in B cells, is required for humoral immunity. PNAS; 105(4); (2008):1273-8

19.     Dong Z, Zhang J, Sun R, Wei H, Tian Z. Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice. Hepatology;45(6); (2007):1400-12.

20.     Veillette A, Dong Z, Latour S. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity; 27(5); (2007):698-710.

21.     Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology; 46(3); (2007):706-15.

22.     Wang J, Sun R, Wei H, Dong Z, Gao B, Tian Z. Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism. Journal of Hepatology; 44(3) ;(2006):446-54.

23.     Dong Z, Tian Z. APC-independent NK cell activation. Journal of Immunology. 2005 15;175(4):2041

24.     Dong Z, Wei H, Sun R, Hu Z, Gao B, Tian Z. Involvement of natural killer cells in Poly I:C- induced liver injury. Journal of Hepatology; 41(6) ;(2004):966-73.


联系方式

Email: dongzj at biowww.sfrecs.com

Phone: 86-10-62785852

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