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基础医学系

履历

    2017–至今,清华大学,医学院基础医学系,助理研究员

    2011–2017,清华大学,医学院基础医学系,博士后

    2006–2011, 中国科学院生物物理研究所(清华大学联合培养),生物化学与分子生物学专业,理学博士

    2002–2006,山东大学,生命科学学院,生物技术系,理学学士


研究领域与方向

以结构生物学为主要研究手段,主要从事参与转录调控的关键表观遗传因子,特别是识别组蛋白修饰的阅读器蛋白以及新型组蛋白修饰的结构与功能研究,同时致力于基于结构的表观遗传靶向药物开发。



学术荣誉与奖励

关键词

代表性论文

[1] Liling Wan*, Hong Wen*, Yuanyuan Li*, Jie Lyu, Takayuki Hoshii, Julia Joseph, Xiaolu Wang, Yong-Hwee E. Loh, Michael A. Erb, Amanda L.Souza, James E. Bradner, Li Shen, Wei Li, Haitao Li, C.David Allis, Scott A.Armstrong, Xiaobing Shi. ENL links histone acetylation to oncogenic gene expression in AML. Nature 2017, doi:10.1038/nature21687.( *共同第一作者,已在线发表,2017年3月9日正式发表)

[2] Xiaozhe Xiong, Tatyana Panchenko, Shuang Yang, Shuai Zhao, Peiqiang Yan, Wenhao Zhang, Wei Xie, Yuanyuan Li*, Yingming Zhao, C. David Allis, Haitao Li. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.Nat Chem Biol 2016,12(12): 1111-1118.(*高级作者,发现了DPF偏性识别组蛋白巴豆?;奘蔚哪芰?

[3] Yuanyuan Li*, Dan Zhao, Zhonglei Chen, Haitao Li.YEATS domain: Linking histone crotonylation to gene regulation.Transcription 2017,8(1): 9-14.(特邀综述, *第一作者). 

[4] Na Li*, Yuanyuan Li*, Jie Lv*, Xiangdong Zheng, Hong Wen, Hongjie Shen, Guangjing Zhu, Tsai-Yu Chen, Shilpa S. Dhar, Pu-Yeh Kan, Zhibin Wang, Ramin Shiekhattar, Xiaobing Shi, Fei Lan, Kaifu Chen, Wei Li, Haitao Li, and Min Gyu Lee. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.Mol Cell 2016,63: 470-484.(*共同第一作者)

[5] Dan Zhao, Haipeng Guan, Shuai Zhao, Wenyi Mi, Hong Wen, Yuanyuan Li, Yingming Zhao, C David Allis, Xiaobing Shi, Haitao Li. YEATS2 is a selective histone crotonylation reader.Cell Research 2016,26: 629-632. 

[6] Yuanyuan Li*, Benjamin R. Sabari*, Tatyana Panchenko*, Hong Wen, Dan Zhao, Haipeng Guan, Liling Wan, He Huang, Zhanyun Tang, Yingming Zhao, Robert G. Roeder, Xiaobing Shi, C. David Allis, Haitao Li. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Mol Cell 2016,62: 181-193.(*共同第一作者) 

[7] Shuai Zhao, Xiaonan Su, Yuanyuan Li, Haitao Li.Research advances in the mechanism of histone methylation recognition by reader modules [J]. Science and Technology Review 2015,33(8): 94-100.(特邀综述)

[8] Yuanyuan Li*, Hong Wen, Xiaobing Shi and Haitao Li. Determination of Protein-DNA (ZMYND11-DNA) Interaction by a Label-Free Biolayer Interferometry Assay.www.bio-protocol.org, 2015.(特邀方法报告,*第一作者)

[9] Yuanyuan Li*, Hong Wen*, Yuanxin Xi, Kaori Tanaka, Haibo Wang, Danni Peng, Yongfeng Ren, Qihuang Jin, Sharon Y.R. Dent, Wei Li, Haitao Li, Xiaobing Shi.AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation.Cell 2014,159(3): 558-71.(*共同第一作者)

[10] Hong Wen, Yuanyuan Li, Haitao Li, Xiaobing Shi.ZMYND11: An H3.3-specific reader of H3K36me3.Cell cycle 2014,13(14):1-2.

[11] Jiabin Li*, Yuanyuan Li*, Qiaoqiao He, Yiming Li, Haitao Li, Lei Liu. One-pot native chemical ligation of peptide hydrazides enables total synthesis of modified histones.Organic & Biomolecular Chemistry 2014,12,5435-5441.(*共同第一作者)

[12] Hong Wen*, Yuanyuan Li*, Yuanxin Xi*, Shiming Jiang, Sabrina Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia, Jun Wu, Bing Li, Michelle C Barton, Wei Li, Haitao Li, Xiaobing Shi.ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.Nature 2014,508,263-268.(*共同第一作者) 

[13] Yuanyuan Li*, Haitao Li. Many keys to push: diversifying the 'readership' of plant homeodomain fingers. Acta Biochimica et Biophysica Sinica 2012,44(1): 28-39.(特邀综述, *第一作者)


联系方式

Email: liyuanyuan at tsinghua.edu.cn

Phone: 010-62796944

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