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基础医学系

履历

    2014- 至今 清华大学 研究员
    2011-2014 洛克菲勒大学 博士后
    2009-2011 基因泰克公司 博士后
    2003-2009 美国德州大学西南医学中心 博士
    1998-2002 清华大学 理学学士

研究领域与方向

1.Inflammation and diseases

2.Metabolic homeostasis and disorders 

3.Neuronal regulation of homeostasis



学术荣誉与奖励

    2018   Young Investigator Award, Lipid Metabolism and Bioenergetics Subsociety of the Biophysical Society of China

    2016   Outstanding Young Scholar Award, Qiu-Shi Science & Technologies Foundation

    2015   Young Investigator Award


关键词

Innate immunity, metabolism and neuroinflammation, signal transduction

代表性论文

1.   Wang Q*, Zhang S*, Liu T*, Wang H, Liu K, Wang Q, Zeng W. Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries. Cell Reports, 2018, in press (* first-authors contributed equally)

2.   Cao Y, Wang H, Zeng W. Whole-Tissue 3D Imaging Reveals Intra-Adipose Sympathetic Plasticity Regulated by NGF - TrkA Signal in Cold-Induced Beiging. Protein & Cell, 2018 Mar 27.

3.   Jiang H*, Ding X*, Cao Y, Wang H, Zeng W. Dense intra-Adipose sympathetic arborizations are essential for cold-induced beiging of mouse white adipose tissues.  Cell Metabolism. 2017 Oct 3; 26(4): 686-692.e3. (* first-authors contributed equally)

4.   Zeng W*, Pirzgalska RM*, Pereira MM, Kubasova N, Barateiro A, Seixas E, Lu YH, Kozlova A, Voss H, Martins GG, Friedman JM, Domingos AI. Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis. Cell. 2015 Sep 24; 163(1): 84-94. (* first-authors contributed equally)

5.   Peng Y*, Zeng W*, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA. A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions. Chem Biol. 2015 Aug 20; 22(8): 1134-43. (* first-authors contributed equally)

6.   Zeng W*, Lu YH*, Lee J, Friedman JM. Reanalysis of parabiosis of obesity mutants in the age of leptin. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3874-82. (* first-authors contributed equally)

7.   Glasmacher E*, Agrawal S*, Chang AB*, Murphy TL*, Zeng W*, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM, Singh H. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012 Nov 16; 338(6109): 975-80. (* first-authors contributed equally)

8.   Rutz S, Noubade R, Eidenschenk C, Ota N, Zeng W, Zheng Y, Hackney J, Ding J, Singh H, Ouyang W. Transcription factor c-Maf mediates the TGF-?-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 2011 Oct 16; 12(12): 1238-45, 2011

9.   Zeng W*, Sun L*, Jiang X, Chen X, Hou F, Adhikari A, Xu M, Chen ZJ. Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell. 2010 Apr 16; 141(2): 315-30. (* first-authors contributed equally)

10.   Zeng W, Xu M, Liu S, Sun L, Chen ZJ. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell. 2009 Oct 23; 36(2): 315-25.

11.   Zeng W, Chen ZJ. MITAgating viral infection. Immunity. 2008 Oct 17; 29(4): 513-5.

12.   Xu M, Skaug B, Zeng W, Chen ZJ. A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23; 36(2): 302-14

13.   Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009 Sep 3; 461(7260): 114-9.

14.   Yang M, Xu G, Li S, Sun L, Shi N, Zeng W, Pang H, Zhang W, Rao Z. Crystallization and preliminary crystallographic analysis of the extracellular fragment of FcalphaRI/CD89. Acta Crystallogr D Biol Crystallogr. 2003 59(Pt 12): 2251-3.

15.   Sun ZH, Lai YL, Zeng WW, Zhao D, Ye ZW, Zuo HC, Xie ZP. Mesencephalic progenitors can improve rotational behavior and reconstruct nigrostriatal pathway in PD rats. Acta Neurochir Suppl. 2003 87:175-80.

16.   Sun ZH, Lai YL, Zeng WW, Zhao D, Zuo HC, Xie ZP. Neural stem/progenitor cells survive and differentiate better in PD rats than in normal rats. Acta Neurochir Suppl. 2003 87:169-74.


联系方式

Email: wenwenzeng at tsinghua.edu.cn

Phone: +86-10-62782861

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