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基础医学系

履历

    2005-至今   清华大学医学院教授

    1998-2004  清华大学医学院副教授

    1997-1998  美国阿拉巴马大学伯明翰分校病理系博士后

    1996-1997  美国华盛顿大学 ( 圣路易斯 ) 医学中心交换学者培训

    1995-1996  美国圣路易斯大学医学院药理及生理系交换学者培训

    1986-1989  西北农业大学动物科学系动物遗传育种专业博士

    1982-1985  西北农业大学动物科学系动物遗传育种专业硕士

    1978-1982  西北农业大学畜牧兽医系畜牧学专业学士


研究领域与方向

细胞信号传导与疾病的关系,重点研究 TGF-β, STAT3, Wnt,FGF 等信号通路中关键蛋白的泛素化及磷酸化修饰,研究这些信号通路异常与肿瘤发生及类风湿性关节炎发生发展的关系,寻找治 疗肿瘤及类风湿性关节炎的药物靶点。

1. Roles of CREPT in the regulation of transcription during tumorigenesis.

2. The role of JAK-STAT pathway in tumorigenesis and inflammation.

3. Regulation of Wnt signaling in tumors.


学术荣誉与奖励

关键词

cancer, gene regulation, signal transduction, Molecular and Cellular Cancer Biology

代表性论文

1.         Xuanzi Fan#, Juan Zhao#, Fangli Ren, Yinyin Wang, Yarui Feng, Lidan Ding, Linpeng Zhao, Jun Li, Jianquan Ni, Baoqing Jia, Zhijie Chang*. Dimerization of p15RS mediated by a leucine-zipper-like motif is critical for its inhibitory role on Wnt signaling. J. Biol. Chem.2018, Accepted.

2.         Tingyu Wang, Shan Li, Dan Yi, Guangqian Zhou, Zhijie Chang, Peter Ma, Guozhi Xiao, Di Chen. CHIP Regulates Bone Mass by Targeting Multiple TRAF Family Members in Bone Marrow Stromal Cells. Bone Research, 2018 Mar 29;6:10.

3.         Yan-Shen Kuang, Yi Wang, Li-Dan Ding, Liu Yang, Ying Wang, Si-Han Liu, Bing-Tao Zhu, Xu-Ning Wang, Hong-Yi Liu, Jun Li, Zhi-Jie Chang, Yin-Yin Wang*, Bao-Qing Jia*. Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil. World J Gastroenterol. 2018 Jan 28;24(4):475-483.

4.         Youzhou Sang, Yanxin Li*, Lina Song, Angel Alvarez, Weiwei Zhang, Deguan Lv, Jianming Tang, Feng Liu, Zhijie Chang, Shigetsugu Hatakeyama, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng*. TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3. Cancer Research, 2018 Apr 1;78(7):1792-1804.

5.         Yanquan Zhang, Shiyan Wang, Wei Kang, Chunxiao Liu, Yujuan Dong, Fangli Ren, Yinyin Wang, Jinglin Zhang, Guoping Wang, Ka-Fai To, Xueji Zhang, Joseph Sung, and Zhijie Chang*, Jun Yu*. CREPT facilitates colorectal cancer growth through inducing Wnt/b-catenin pathway by enhancing p300-mediated b-catenin acetylation. OncogeneOncogene. 2018 Mar 22. doi: 10.1038/s41388-018-0161-z. [Epub ahead of print] (co-corresponding authors).

6.         Jiao Liang, Ying Qiu, Yinyin Wang, Fangli Ren, Zhijie ChangCREPT expression correlates with esophageal squamous cell carcinoma histological grade and clinical outcome. Int J Clin Exp Pathol 2017;10(2):2030-2035.

7.         Kai Jin, Hao Chen, Qisheng Zuo, Chuanli Huang, Ruifeng Zhao, Xinjian Yu, Yinjie Wang, Yani Zhang, Zhijie Chang, Bichu Li*. CREPT and p15RS regulate cell proliferation and cycling in chicken DF-1 cells through the Wnt/β-catenin pathway. J Cell Biochem. 2018 Jan;119(1):1083-1092.

8.         Zhihao Yang, Jin Sun, Yuzhao Hu, Fang Wang, Xia Wang, Huan-Huan Qiao, Jiang Xu, Decai Mao, Xingjie Ren, Li-Xia Pan, Rong-Gang Xu, Bo-Wen Xu, Yifan Zhang, Haiyi Li, Wei Miao, Yanhui Hu, Zhijie Chang, Dong Wang, Haitao Li, Zai Chang, Lu-Ping Liu, Qingfei Liu, Jian-Quan Ni*. Histone H1 defect in escort cells triggers germline tumor in Drosophila ovary. Developmental Biology. 424, 40-49, 2017.

9.         Ke Xu, Guo Chen, Xiaobo Li, Xiaoquin Wu, Zhijie Chang, Jianhua Xu, Yu Zhu, Peihao Yin, Xin Liang and Lei Dong*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Scientific Report. 2017, 7:41718 | DOI: 10.1038/srep41718.

10.     Yu Shang, Jinjun He, Yinyin Wang, Quanling Feng, Yanquan Zhang, Junwei Guo, Jun Li, Shan Li, Yangmeng Wang, Ge Yan, Fangli Ren, Yuguang Shi, Jiake Xu, Nikolajs Zeps, Yonggong Zhai, Dacheng He, and Zhijie Chang*. CHIP/Stub1 Regulates the Warburg Effect by Promoting Degradation of PKM2 in Ovarian Carcinoma. Oncogene. 36(29):4191-4200, Jul 20, 2017.

11.     Li Ma, Chao Huang*, Dazhuan Eric Xin, Xiong-Jun Wang, Li-shun Wang, Quanli C. Zou, Ya-nan S. Zhang, Min-dian Tan, Yu-mei Wang, Ting C. Zhao, Devasis Chatterjee, Rachel A. Altura, Chuangui Wang, Yan S. Xu, Jing-hua Yang, Yong-sheng Fan, Bao-hui Han, Jianmin Si, Jinke Cheng, Zhijie Chang*, Y. Eugene Chin*. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell, 65(2), 296–309, 2017 (co-corresponding authors).

12.     Chao Wang, Xi Liu, Zhengyuan Li, Yijie Chai, Yunfeng Jiang, Qian Wang, Yewei Ji, Zhongli Zhu, Ying Wan, Zhenglong Yuan, Zhijie Chang and Minghui Zhang*. CD8+NKT-like cells regulate the immune response by killing antigen-bearing DCs. Scientific Report. 5:14124-14137, 2015.

13.     Zhu GFan ZDing MZhang HMu LDing YZhang YJia BChen LChang ZWu W*. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. Mar 9. doi: 10.1038/onc.2015.45, 2015. [Epub ahead of print]

14.     Fangli Ren, Yongtao Geng, Takayuki Minami, Ying Qiu, Yarui Feng, Chunxiao Liu, Juan Zhao, Yinyin Wang, Xuanzi Fan, Yangmeng Wang, Mengdi Li, Jun Li*, and Zhijie Chang*. Nuclear termination of STAT3 signaling through the SIPAR (STAT3-Interacting Protein As a Repressor) adaptor recruiting T cell tyrosine phosphatase TC-PTP. FEBS Letters. Jul 8;589(15):1890-6 2015.

15.     Chunxiao Liu, Yanquan Zhang, Jun Li, Yinyin Wang, Fangli Ren, Yifan Zhou, Yinyuan Wu, Yarui Feng, Yu Zhou, Fuqin Su, Baoqing Jia, Dong Wang, and Zhijie Chang*. p15RS(p15INK4b Related Sequence)/RPRD1A (Regulation of Nuclear Pre-mRNA Domain-Containing Protein 1A) Interacts with HDAC2 (Histone Deacetylase 2) in Inhibition of the Wnt/?-catenin Signaling Pathway. J. Biol. Chem. Feb 19. pii: jbc.M114.620872, 2015. [Epub ahead of print].

16.     Shigao Yang, Yinyin Wang, Kunrong Mei, Sen Zhang, Xiaojun Sun, Fangli Ren, Sihan Liu, Zi Yang, Xinquan Wang, Zhihai Qin, Zhijie Chang*. TNFR2–IL-17RD heteromerization reveals a novel mechanism for NF-κB activation. J. Biol. Chem. 2015 Jan 9;290(2):861-71. doi: 10.1074/jbc.M114.586560. Epub 2014 Nov 5.

17.     Shiyan wang, Yujuan Dong, Yanquan Zhang, Lixia Xu, Shigao Yang, Xiaoxing Li, Haifeng Dong, Liping Xu, Lei Su, Simon SM Ng, Zhijie Chang, JJ Sung, Xueji Zhang, and Xiaojuan Wang and Jun Yu*. DACT2 is a functional tumor suppressor through inhibiting Wnt/?-catenin pathway and associated with poor survival in colon cancer. Oncogene. 34:2575-2585, 2015.

18.     Fangli RenRuoke WangYanquan ZhangChunxiao LiuYinyin WangJim HuLinqi Zhang, and Zhijie Chang*. Characterization of a Monoclonal Antibody Against CREPT, a Novel Protein Highly Expressed in Tumors. Monoclon Antib Immunodiagn Immunother. 33(6): 401–408, 2014.

19.     Yanquan Zhang, Chunxiao Liu, Xiaolin Duan, Fangli Ren, Zhe Jin, Shan Li, Yinyin Wang, Yarui Feng, Zewen Liu and Zhijie Chang*. CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the ?-catenin/TCF4 Transcriptional Activity in Response to Wnt Signaling. J. Biol. Chem. 289(33):22589-99, 2014.

20.     Yaoguang SheJiao LiangLin ChenYing QiuNa LiuXudong ZhaoXiaohui HuangYinyin WangFangli RenZhijie ChangPeiyu Li*. CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma. Int J Clin Exp Pathol. 2014; 7(10): 6596–6605.

21.     Ye Bu, Fuqin Su, Xu Wang, Hai Gao, Lei Lei, Nannan Chang, Qing Wu, Keping, Hu, Xiaojun Zhu, Zhijie Chang, Kun Meng, and Jing-Wei Xiong*. Protein Tyrosine Phosphatase PTPN9 Regulates Erythroid Cell Development through STAT3 Dephosphorylation in Zebrafish. Journal of Cell Science. 127(Pt 12):2761-70, 2014.

22.     Yongtao Geng, Yanfang Ju, Fangli Ren, Ying Qiu, Yasuhiko Tomita, Miki Tomoeda, Mioka Kishida, Yinyin Wang, Lian Jin, Fuqin Su, Chunhong Wei, Baoqing Jia, Yi Li*, Zhijie Chang*. Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-catenin Signaling through Blocking Autophagic Degradation of Dishevelled2. J. Biol. Chem. Apr 18; 289(16): 11230-41, 2014. (co-corresponding authors)

23.     Huabing Qi, Min Jin, Yaqi Duan, Xiaolan Du, Yuanquan Zhang, Fangli Ren, Yinyin Wang, Qingyun Tian, Xiaofeng Wang, Quan Wang, Ying Zhu, Yangli Xie, Chuanju Liu, Xu Cao, Yuji Mishina, Di Chen, Chu-xia Deng, Zhijie Chang*, Lin Chen*. FGFR3 induces degradation of BMP type I receptor to regulate skeletal development. BBA-Molecular Cell Research. Jul; 1843(7): 1237-47, 2014. (co-corresponding authors)

24.     Yu Shang, Xialian Xu, Xiaolin Duan, Junwei Guo, Yinyin Wang, Fangli Ren, Dacheng He and Zhijie Chang*. Hsp70 and Hsp90 oppositely regulate TGF-? signaling through CHIP/Stub1. Bioch. Bioph. Res. Com. 421:651-657, 2014.

25.     Shan Li, Bing Shu, Yanquan Zhang, Jia Li, Junwei Guo, Yinyin Wang, Fangli Ren, Guozhi Xiao, Zhijie Chang*, and Di Chen*. CHIP Regulates Osteoclast Formation through Promoting TRAF6 Protein Degradation. Arthritis & Rheumatology. 66(7):1854-1863, 2014. (co-corresponding authors)

26.     Yu Shang, Xinghui Zhao, Bo Tian, Yinyin Wang, Fangli Ren, Baoqing Jia, Yonggong Zhai, Dacheng He, Wei Chen and Zhijie Chang*. CHIP/Stub1 interacts with eIF5A and mediates its degradation. Cellular Signalling. 26: 1098-1104, 2014.

27.     Yangmeng Wang, Hongxiu Ning, Fangli Ren, Yuanjiang Zhang, Yu Rong, Yinyin Wang, Fuqin Su, Chenguang Cai, Zhe Jin, Zhiyong Li, Xinqi Gong, Yonggong Zhai, Dianjun Wang, Baoqing Jia, Ying Qiu, Yasuhiko Tomita, Joseph JY Sung, Jun Yu, David M. Irwin, Xiao Yang, Xinyuan Fu, Y. Eugene Chin*, and Zhijie Chang*. GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis. Mol Cell53:752-765, 2014.

28.     Yangmeng Wang, Fangli Ren, Yinyin Wang, Yarui Feng, Dianjun Wang, Baoqing Jia, Ying Qiu, Shiyan Wang, Jun Yu, Joseph JY Sung, Jiake Xu, Nikolajs Zeps, and Zhijie Chang*. CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer. Carcinogenesis. May;35(5):983-91, 2014.

29.     Mei KunRong, Jin Zhe, Ren Fangli, Wang Yinyin, Chang Zhijie*, Wang Xinquan*. Structure basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS. Science China Life Sciences. Volume 57, Number 1:97-106, 2014. (co-corresponding authors)

30.     Hongge Li, Songchang Guo, Yongming Ren, Depeng Wang, Honghao Yu, Wenjing Li, Xinquan Zhao, and Zhijie Chang*VEGF189 Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes. HIGH ALTITUDE MEDICINE & BIOLOGY. Volume 14, Number 4, 2013.

31.     Li, Yirong; Tian, Liantian; Ligr, Martin; Daniels, Garrett; Peng, Yi; Wu, Xinyu; Singh, Mandeep; Wei, Jianjun; Shao, Yongzhao; Lepor, Herbert; Xu, Ruliang; Chang, Zhijie; Wang, Zhengxin; Lee, Peng*. Functional Domains of Androgen Receptor Coactivator p44/Mep50/WDR77and Its Interaction with Smad1. PLOS ONE. 8:64663, 2013.

32.     Wang JZhao JChu ESMok MTGo MYMan KHeuchel RLan HYChang ZSung JJYu J*. Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro. J Pathol. 2013 Aug;230(4):441-52. doi: 10.1002/path.4206.

33.     Fangli Ren, Fuqin Su, Hongxiu Ning, Yangmeng Wang, Yongtao Geng, Yarui Feng, Yinyin Wang, Yanquan Zhang, Zhe Jin, Yi Li, Baoqing Jia and Zhijie Chang*. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. Cellular Signalling. 25:2272-2280, 2013.

34.     Xiaojun Sun, Yinyin Wang, Shigao Yang, Fangli Ren, Yongjing Xia, Zhijie Chang*. Activation of TAK1 by Sef-S induces apoptosis in 293T cells. Cellular Signalling. 25:2039-2046, 2013.

35.     W Du , S Wang, Q Zhou, X Li, J Chu, Z Chang, Q Tao, EKO Ng, J Fang, JJY Sung and J Yu*. ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. Oncogene. 32(28):3319-28, 2013.

36.     Jia Nie, Chao Sun, Omar Faruque, Guangming Ye, Jia Li, Qiangrong Liang, Zhijie Chang, Wannian Yang, Xiao Han, and Yuguang Shi*. Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-Stimulated Insulin Secretion through Activation of p21-Activated Kinase (PAK1) in Pancreatic β-Cells. J. Biol. Chem. 287(31):26435-44, 2012.

37.     Xi Yang, Yanquan Zhang, Shan Li, Chunxiao Liu, Zhe Jin, Yinyin Wang, Fangli Ren, Zhijie Chang*. Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation. Bioch. Bioph. Res. Com. 421:651-657, 2012

38.     Junwei Guo, Fangli Ren, Yinyin Wang, Shan Li, Zhengrong Gao, Xiaoyan Wang, Hongxiu Ning, Jianguo Wu, Yi Li, Zhao Wang, Shek Man Chim, Jiake Xu, and Zhijie Chang*. miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. Journal of Bone and Mineral Research. 2012 Mar 9. doi: 10.1002/jbmr.1597. [Epub ahead of print]

39.     Fuqin Su, Fangli Ren, Yu Rong, Yangmeng Wang, Yongtao Geng, Yinyin Wang, Mengyao Feng, Yanfang, Ju Yi Li, Zhizhuang J. Zhao, Kun Meng*, Zhijie Chang*Protein tyrosine phosphatase Meg2 dephosphorylates STAT3 and suppresses tumor growth in the breast cancer. Breast Cancer Research. 2012 Mar 6;14(2):R38. [Epub ahead of print].

40.     Shan Zhong, Jia-He Yang, Kai Liu, B H Jiao and Zhijie Chang*. Null genotype of glutathione S-transferase Tl contributes to colorectal cancer risk in the Asian population: A meta-analysis. Journal of Gastroenterology and Hepatology. 27(2):231-237, 2012.

41.     Jun Yu, Qiaoyi Liang, Jia Wang, Yingduan Cheng, Shiyan Wang, Terence CW Poon, Minnie YY Go, Qian Tao, Zhijie Chang, Joseph JY Sung*. Zinc Finger Protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer. Oncogene. 2012 Feb 27. doi: 10.1038/onc.2012.54. [Epub ahead of print].

42.     Dongdong Lu, Yinyuan Wu, Yinyin Wang, Fangli Ren, Dianjun Wang, Fuqin Su, Yanquan Zhang, Xi Yang, Guihua Jin, Xinbao Hao, Dacheng He, Yonggong Zhai, David M Irwin, Jim Hu, Joseph JY Sung, Jun Yu, Baoqing Jia*, Zhijie Chang*. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle related genes. Cancer Cell. 21:92-104, 2012.

43.     Yangmeng Wang, Dianjun Wang, Fangli Ren, Yuanjiang Zhang, Fuyu Lin, Ning Hou, Xuan Cheng, Peng Zhang, Yinyin Wang, Baoqing Jia, Xiao Yang and Zhijie Chang*. Generation of mice with conditional null allele for GdX/Ubl4A. Genesis. 50:534-542, 2012.

44.     Rahul Kushwah, Jing Wu, Jordan R Oliver, Zhijie Chang and Jim Hu*. Elf3 regulates allergic airway inflammation by controlling dendritic cell driven T cell differentiation. J Immunol. 187(9):4639-53, 2011.

45.     Dewei Jia, Wei Rao, Chao Wang, Chao Jin, Suqiong Wang, Dongwei Chen, Minghui Zhang, Junwei Guo, Zhijie Chang, Jing Liu*. Inhibition of B16 murine melanoma metastasis and enhancement of immunity by fever-range whole body hyperthermia. International Journal of Hyperthermia. 27(3):275-85, 2011.

46.     Yanquan Zhang, Fang Wang, Liang Han, Yinyuan Wu, Shan Li, Xi Yang, Yinyin Wang, Fangli Ren, Yonggong Zhai, Dianjun Wang, Baoqing Jia, Yongjing Xia, and Zhijie Chang*. GABARAPL1 negatively regulates Wnt/?-catenin pathway by mediating Dvl2 degradation through autophagy pathway. Cellular Physiology and Biochemistry. 27:503-512, 2011.

47.     Xiaoyan Wang, Kenichi Harimoto, Jing Liu, Junwei Guo, Stephen Hinshaw, Zhijie Chang*, Zhao Wang*. Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway. Journal of Bone and Mineral Research 26(8):1964-73, 2011. (co-corresponding authors).

48.     Yinyuan Wu, Dianjun Wang, Yinyin Wang, Fangli Ren, Donald Chang, Zhijie Chang* and Baoqing Jia*. Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells. Cellular Physiology and Biochemistry. 27:539-546, 2011. (co-corresponding authors).

49.     Xinbao Hao, Yinyin Wang, Fangli Ren, Shanshan Zhu, Yongming Ren, Baoqing Jia, Yi-Ping Li, Yuguang Shi and Zhijie Chang*. SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Cellular Signalling. 23(5):935-946, 2011.

50.     Wang L. Liu YT, Hao R, Chen L, Chang Z, Wang HR, Wang ZX, Wu JW*. Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J. Biol. Chem. 286(18): 15883-94, 2011.

51.     Wei-Ren Li, Liang Chen, Zhi-Jie Chang, Hua Xin, Tao Liu, Yan-Quan Zhang, Guang-Yong Li, Feng Zhou, Yan-Qing Gong, Zhe-Zhu Gao and Zhong-Cheng Xin*. Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells. Asian Journal of Andrology. 13(6):881-888, 2011.

52.     Yinyuan Wu, Yanquan Zhang, Haiwei Zhang, Xi Yang, Yinyin Wang, Fangli Ren, Huitu Liu, Yonggong Zhai, Baoqing Jia, Jun Yu, and Zhijie Chang*. p15RS attenuates Wnt/β-catenin signaling by disrupting β-catenin/TCF4 interaction. J. Biol. Chem. 285(45):34621-34631, 2010.

53.     Tianyao Yang, Rongqi Duan, Huibi Cao, Benjamin H. Lee, Chun Xia, Zhijie Chang, A. Keith Tanswell and Jim Hu*. Development of an inflammation-inducible gene expression system using helper-dependent adenoviral vectors. Journal of Gene Medicine. 12:832-839, 2010.

54.     Haiwei Zhang, Hui Zhang, Yanquan Zhang, Ser Sue Ng, Fangli Ren, Yingying Wang, Yaqi Duan, Lin Chen, Yonggong Zhai, Qinglong Guo*, and Zhijie Chang*. Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/?-catenin complex. Cellular Signalling. 22:1753-1760, 2010. (co-corresponding authors).

55.     Jia Li, Caroline Romestaing, Xianlin Han, Yuan Li, Xinbao Hao, Yinyuan Wu, Chao Sun, Leonard S. Jefferson, Jingwei Xiong, Kathryn F. LaNoue, Zhijie Chang, Christopher J. Lynch, Huayan Wang and Yuguang Shi*. Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity. Cell Metabolism. 12:154-165, 2010.

56.     Jing Nie, Ping Xie, Lin Liu, Guichun Xing, Zhijie Chang, YuxinYin, Chunyan Tian*, Fuchu He*, Lingqiang Zhang*. Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J. Biol. Chem. 285(30): 22818-30, 2010.

57.     Yinyuan Wu, Yinyin Wang, Yang Sun, Liying Zhang, Dianjun Wang, Fangli Ren, Donald Chang, Zhijie Chang* and Baoqing Jia*. RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL. Cellular Signalling. 2010; 22:1495-1501. (co-corresponding authors)

58.     Jia Nie, Xinbao Hao, Daohong Chen; Xiao Han, Zhijie Chang, Yuguang Shi*. A Novel Function of the Human CLS1 in Phosphatidylglycerol Synthesis and Remodeling. BBA - Molecular and Cell Biology of Lipids. 2010 Apr; 1801(4):438-45.

59.     Zhihao Wu, Xiaoai Zhang, Juntao Yang, Guangzhou Wu, Ying Zhang, Yanzhi Yuan, Chaozhi Jin, Zhijie Chang, Jian Wang, Xiaoming Yang, Fuchu He*. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Bioch. Bioph. Res. Com. 2009 Sep 18;387(2):348-52.

60.     Yu Shang, Xinghui Zhao, Xialian Xu, Hong Xin, Xueni Li, Yonggong Zhai, Dacheng He, Baoqing Jia, Wei Chen, and Zhijie Chang*. CHIP functions as an E3 ubiquitin ligase of Runx1. Bioch. Bioph. Res. Com. 386:242-246, 2009.

61.     Zhen Qin, Fangli Ren, Xialian Xu, Yongming Ren, Hongge Li, Yinyin Wang, Yonggong Zhai, and Zhijie Chang*. ZNF536, A Novel Zinc Finger Protein Specifically Expressed In The Brain, Negatively Regulates Neuron Differentiation Via Repressing RA-Induced Gene Transcription. Mol. Cell. Biol. 29:3633-43, 2009.

62.     Jingsong Cao, Weiqun Shen, Zhijie Chang, and Yuguang Shi*. ALCAT1 Is a Polyglycerophospholipid Acyltransferase Potently Regulated by Adenine Nucleotide and Thyroid Status. American Journal of Physiology-Endocrinology and Metabolism.  296:E647-E653, 2009.

63.     Zhili Rong, Andrew Wang, Zhiyong Li, Yongming Ren, Long Cheng, Yinghua Li, Yinyin Wang, Fangli Ren, Xiaoning Zhang, Jim Hu and Zhijie Chang*. IL-17RD (Sef or IL-17RLM) Interacts with IL-17 Receptor and Mediates IL-17 Signaling. Cell Research. 19:208-215, 2009.

64.     Ying-Hua Li, Yin-Yin Wang, Shan Zhong, Zhi-Li Rong, Yong-Ming Ren, Zhi-Yong Li,Shu-Ping Zhang, Zhi-Jie Chang, and Li Liu*. Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling. Molecules and Cells. 27: 39-45, 2009.

65.     Fang Wang, Haiwei Zhang, Xinjun Zhang, Yinyin Wang, Fangli Ren, Xiaoning Zhang, Yonggong Zhai*, and Zhijie Chang*. Varp interacts with Rab38 and functions as its potential effector. Bioch. Bioph. Res. Com. 372:162-167, 2008.

66.     Xueni Li, Mei Huang, Huiling Zheng, Yinyin Wang, Fangli Ren, Yu Shang, Yonggong Zhai, David M. Irwin, Yuguang Shi, Di Chen, and Zhijie Chang*. CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation.  Journal of Cell Biology. 181(6):959-972, 2008.

67.     Yongming Ren, Long Cheng, Zhili Rong, Zhiyong Li, Yinghua Li, Xinjun Zhang, Shiqin Xiong, Jim Hu, Xin-Yuan Fu, Zhijie Chang*. hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation. Cellular Signalling. 20:518-533, 2008.

68.     Ying-Hua Li, Zhijie Chang, Li Liu*. NOK Interacts with Akt and Enhances Its Activation. Pro. Biochem. Biophys. 35(1), 29-34, 2008.

69.     Ying-Hua Li, Yu Rong, Zhijie Chang, Li Liu*. NOK Activates STAT3 Signaling by a JAK2-dependent Mechanism. Pro. Biochem. Biophys. 35(2), 143-150, 2008.

70.     REN Yong-Ming, RONG Zhi-Li, Li Zhi-Yong, CHENG Long, LI Ying-Hua, WANG Yin-Yin, REN Fang-Li, David M. Irwin, CHANG Zhijie*. c-Cbl mediated ubiquitination and degradation of hSef. Pro. Biochem. Biophys. 35(1), 43-49, 2008.

71.     Ren-Feng Li, Yu Shang, Di Liu, Ze-Song Ren, Zhijie Chang*, Sen-Fang Sui*. Differential Ubiquitination of Smad1 Mediated by CHIP: Implications in the Regulation of the Bone Morphogenetic Protein Signaling Pathway. Journal of Molecular Biology. 374:777-790, 2007. (co-corresponding authors).

72.     Zhili Rong, Long Cheng, Yongming Ren, Zhiyong Li, Yinghua Li, Xueni Li, Hongge Li, Xin-Yuan Fu, Zhijie Chang*. Interleukin-17F Signaling Requires Ubiquitination of Interleukin-17 Receptor via TRAF6. Cellular Signalling. 19:1514-1520, 2007.

73.     Ying-Hua Li, Shan Zhong, Zhi-Li Rong, Yong-Ming Ren, Zhi-Yong Li, Shu-Ping Zhang, Zhijie Chang, Li Liu*. The Carboxyl Terminal Tyrosine 417 Residue of NOK Has an Autoinhibitory Effect on NOK-mediated Signaling Transductions. Bioch. Bioph. Res. Com. 356(2):444-449, 2007.

74.     Sen Liu, Shiyong Liu, Xiaolei Zhu, Huanhuan Liang, Aoneng Cao, Zhijie Chang, Luhua Lai*. Non-natural Protein-Protein Interaction-Pair Design: a PH Domain Designed to Bind with EPO Receptor by Key Residues Grafting. Proc. Natl. Acad. Sci. USA. 104(13): 5330-5335, 2007.

75.     Yongming Ren, Zhiyong Li, Zhili Rong, Long Cheng, Yinghua Li, Zhen Wang, Zhijie Chang*. Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling. Bioch. Bioph. Res. Com. 354: 741-746, 2007.

76.     Zhijie Chang, Lorne A Babiuk, Jim Hu*. Therapeutic and Prophylactic Potential of siRNAs against SARS: Progress to Date. BioDrugs. (Invited review). 21: 9-15, 2007.

77.     Yongming Ren, Long Cheng, Zhili Rong, Zhiyong Li, Yinghua Li, Hongge Li, Zhen Wang, Zhijie Chang*. hSef co-localizes and interacts with Ras in the inhibition of Ras/MAPK signaling pathway. Bioch. Bioph. Res. Com. 347: 988-993, 2006.

78.     Zhili Rong, Yongming Ren, Long Cheng, Zhiyong Li, Yinghua Li, Yang Sun, Hongge Li, Shiqin Xiong, and Zhijie Chang*. Sef-S, an alternative splice isoform of sef gene, inhibits NIH3T3 cell proliferation via a mitogen-activated protein kinases p42 and p44 (ERK1/2)-independent mechanism. Cellular Signalling. 19: 93-102, 2007.

79.     Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang*, and Xin-Yuan Fu*. WT1 and STAT3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. Cancer Research. 66: 8049-8057, 2006. (co-corresponding authors)

80.     Chang PL*, Blair HCZhao XChien YWChen DTilden ABChang ZCao XFaye-Petersen OMHicks P. Comparison of Fetal and Adult Marrow Stromal Cells in Osteogenesis with and without Glucocorticoids. Connect Tissue Res. 47: 67-76, 2006.

81.     Xinjun Zhang, Xi He, Xin-Yuan Fu*, Zhijie Chang*. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. Journal of Cell Science. 119: 1053-62, 2006. (co-corresponding authors)

82.     Tie-Shi Li, Xue-Ni Li, Zhijie Chang, Xinyuan Fu and Li Liu*. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway. Cellular Signalling. 18: 1287-1298, 2006.

83.     Zhijie Chang* and Jim Hu*. RNAi therapeutics: Can siRNAs conquer SARS? News and Commentary (invited). Gene Therapy. 13: 871-872, 2006. (co-corresponding authors)

84.     Yue Chen, Ying-Hua Li, Xi-Ping Chen, Li-Min Gong, Shu-Ping Zhang, Zhijie Chang, Xiu-Fang Zhang*, Xin-Yuan Fu*, Li Liu*. Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Cancer Research. 65: 10838-10846, 2005.

85.     Hong Xin, Xialian Xu, Linyu Li, Hongxiu Ning, Yu Rong, Yu Shang, Yinyin Wang, Xin-Yuan Fu, and Zhijie Chang*. CHIP controls the sensitivity of TGF-? signaling by maintaining the basal level of Smad3 through ubiquitin-mediated degradation. J. Biol. Chem. 280: 20842-20850, 2005.

86.     Tieshi Li, Yuanjiang Zhang, Ling Fu, Changming Yu, Xueni Li, Yinghua Li, Xinjun Zhang, Zhili Rong, Yinyin Wang, Hongxiu Ning, Rong Liang, Wei Chen, Lorne A. Babiuk, and Zhijie Chang*. siRNA targeting Leader sequence of SARS-CoV inhibited the virus replication. Gene Therapy. 12: 751-761, 2005.

87.     Ning Hong-Xiu, Chen Yue, Zhang Yuan-Jiang, Rong Yu, Wu Xiao-Jun, Zhang Xiu-Fang, and Chang Zhi-Jie*. A LIF mutation at the 29th amino acid totally abolished the biological functions. Pro. Biochem. Biophys. 32: 318-324, 2005.

88.     Li Liu, Xin-Zi Yu, Tie-Shi Li, Lian-Xia Song, Pei-La Chen, Ta-Lin Suo, Ying-Hua Li, Shi-Dong Wang, Yue Chen, Yong-Ming Ren, Shu-Ping Zhang, Zhi-Jie Chang, Xin-Yuan Fu*. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Cancer Research. 64: 3491-3499,2004.

89.     Yuanjiang Zhang, Tieshi Li, Ling Fu, Changming Yu, Yinghua Li, Xialian Xu, Yinyin Wang, Hongxiu Ning, Shuping Zhang, Wei Chen, Lorne A Babiuk, and Zhijie Chang*. Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference. FEBS Letters. 560: 141-146, 2004.

90.     Ming Zhang, Shanshan Zhu, Yue Chen, Zhijie Chang, Guoqiang Chen, Yandao Gong, Naming Zhao, Xiufang Zhang*. Studies on bone marrow stromal cells affinity of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate). Biomaterials. 25: 1365-1373, 2004.

91.     Keiko Tamai, Xin Zeng, Chunming Liu, Xinjun Zhang, Yuko Harada, Zhijie Chang, and Xi He*. A mechanism for Wnt co-receptor activation. Molecular Cell. 13: 149-156, 2004.

92.     Linyu Li, Hong Xin, Xialian Xu, Mei Huang, Xinjun Zhang, Yue Chen, Shuping Zhang, Xin-Yuan Fu* and Zhijie Chang*. CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol. Cell. Biol. 24: 856-864, 2004. (co-corresponding authors).

93.     T.B. Zhao, H.X. Ning, S.S. Zhu, P. Sun, S.X. Xu, Z.J. Chang, and X.Q. Zhao*. Cloning of hypoxia-inducible factor 1a cDNA from a high hypoxia tolerant mammal—plateau pika (Ochotona curzoniae). Bioch. Bioph. Res. Com. 316: 565–572, 2004.

94.     Shiqin Xiong, Qiuhui Zhao, Zhili Rong, Guanrong Huang, Yiling Huang, Peila Chen, Shuping Zhang, Li Liu, and Zhijie Chang*. hSef inhibits PC12 cell differentiation by interfering with Ras-Mitogen-activated MAPK signaling. J. Biol. Chem. 278: 50273-50282, 2003.

95.     Ye Xiongjun, Zhang Zhiwen, Zhang Xinjun, Lin Guiting, Xiong Shiqin, Jin Guihua, Han Liang, Huang Shisi, Chen Peila, Ai Junkui, Xin Dianqi, Guo Yinglu, and Chang Zhijie*. Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway. Chinese Science Bulletin. 48: 668-670, 2003.

96.     Lin Guiting, Zhang Zhiwen, Zang Tong, Chang Zhijie, Guo Yinglu* Interaction of hTCF4 by Yeast Two-hybrid. Chinese Science Bulletin. 45: 1973-1976, 2000.

97.     Xingming Shi, Xiangli Yang, Di Chen, Zhijie Chang, and Xu Cao*. Smad1 interacts with homeodomain DNA binding proteins in BMP signaling. J. Biol. Chem. 274: 13711-13717, 1999.


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